Biotechnological product PlantAP (project company Planta, LLC)
PlantAP – innovative biotechnological product, containing human intestinal alkaline phosphatase (AP) for prevention and treatment of systemic inflammatory diseases.
The enzyme intestinal alkaline phosphate plays an important role in the body. It dephosphorylates and thereby inactivates LPS and ATP. Due to this, alkaline alkaline phosphate neutralizes the trigger mechanism of intestinal disorders and the development of systemic inflammatory diseases:
– restores normal intestinal microflora and prevents the development of pathogenic microflora;
– prevents the formation of a cascade of inflammatory reactions in the intestinal wall and disruption of the intestinal barrier (“leaky gut” syndrome);
– prevents the development of inflammatory bowel disease and other systemic inflammatory and autoimmune diseases.
PlantAP is carrot cells, containing recombinant human intracellular AP. The product is made in bioreactors, freeze dried and then used as an enzyme formulation (food supplement, potentially as a drug) in capsules or sachets. Can be used to fortify food products (like pro- and prebiotics).
Patent profile: patented in Russia, patent applications in EAEU, USA, EU, China.
Indications for use: prevention of systemic inflammatory and autoimmune diseases, associated with disorders of microflora and intestinal barrier.
Main advantages:
PlantAP solves a problem not addressed by other drugs or food supplements – prevention of the development of systemic inflammatory diseases, which lead to reduced life quality and expectancy, disability and high mortality in a significant part of the population;
– High safety of the product, its suitability for lifelong use;
– Simple and cheap production technology (compared to analogs produced in mammalian cells and requiring enzyme purification);
– The plant cell is a natural vehicle for safe delivery of human AP into the intestine (competitors use expensive formulations and potentially unsafe bovine AP, which can provoke an immune response);
– Freeze dried plant cells provide long-term stability of AP compared to competitors (which use purified enzyme).
Current status: Laboratory technology of production and cultivation of plant producers, carrot cells with human AP gene, is developed. Preclinical studies in models of dysbiosis and inflammatory bowel diseases are completed, which confirmed high efficacy of the product.
Video: https://youtu.be/5YWnvk5QNsI